Dr. Lakshmi Kiran Chelluri
PhD, FRCPath

About

Dr Lakshmi Kiran Chelluri has obtained her under- graduate, post-graduate degree in Pharmaceutics from BITS (Pilani), & Ph.D (Immunogenetics) from Osmania University. She was awarded BOYSCAST fellowship funded by DST, at LUMC, Chicago. Her Post-doctoral research interest stemmed from Transplant Immunology leading to understanding organ regeneration strategies using multidisciplinary approaches. She is currently working as Head, Department of Advanced Diagnostics & Therapeutics at Global Hospitals. She has 74 peer reviewed international and national publications with H index of 11, authored two books, 4 book chapters & 1 monograph.

She served International Society for Cell & Gene Therapy as Regional Secretary (Asia) for 3 years, & Global Executive Member (Invited Guest) of FACT for 2 years. She is a professional body member of IIS, STERMI. Being quality conscious, she serves as a freelance NABL, Advisory role. Lead and Technical assessor for ISO 15189:2012 (Medical Testing) for Molecular Medicine, and task force member of Emirates International Accreditation Centre (EIAC). She has provided doctoral and post-doctoral guidance to several students of biotechnology.

She has also augmented her skills in Genomic Data Sciences in NGS, from John’s Hopkins University, observer at Salk Biological Research Institute on embryonic stem cell cultures. She was awarded DST-ITS travel grant for presenting research work at ISCGT annual conference. Her post-doctoral guided student DST-RA work has been in the top 15% best work adjudged by the DST.

Her major scientific contributions include process development of segregating cardiac precursors from cardiac and non-cardiac tissue origins by identifying key markers SIRPA & KDR, using MACS, and for cell tracking by MRI in mice model. She has worked extensively on native and extra cellular matrix in liver regeneration and lab grown articular cartilage, using de-cellularization, re-cellularization, chitosan hydrogels. She has collaborative work on communicable disease susceptibility markers and infection mediated inflammatory responses such as Tuberculosis & Sepsis. Particularly, her work on Sepsis includes the identification of biomarkers and understanding the mechanistic pathways of necroptosis, pyroptosis, apoptosis and autophagy.

She has worked on Streptozotocin induced diabetic, Isoproterenol induced cardiac failure disease models for studying the safety and efficacy of differentiated islet cells and cardiomyocytes in organ regeneration. Her work has elucidated the immunomodulatory properties of mesenchymal stem cells, with respect to the secretory IL-10 cytokine, in alleviating the inflammatory arthritis, synovium in in vitro studies. She has demonstrated the Treg and FoxP3 regulation of mesenchymal stem cells in Rheumatoid Arthritis in in vitro experiments. Her current focus is on the development of novel therapeutic strategies using organ-on-a-chip by microfluidics, 3D printing, and translating them from bench to bedside applications.